Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 16, Issue 1, Pages 83-94Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2004.10.003
Keywords
myocardium; endocardium; development; protein-protein interactions; transcription factors
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Funding
- Medical Research Council [MC_U137981013] Funding Source: Medline
- MRC [MC_U137981013] Funding Source: UKRI
- Medical Research Council [MC_U137981013] Funding Source: researchfish
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The transcription factors GATA-4, -5 and -6 are expressed very early in heart tissue. Essential GATA sites have been detected in several cardiac genes and the cardiac GATA factors interact with a wide variety of cofactors which synergistically increase gene expression. These multi-protein transcriptional complexes confer promoter-specificity on the GATA factors and also on the more broadly expressed cofactors. Here we summarise the data on these interactions and represent the conclusions as a GATA factor-based genetic regulatory network for the heart. Of the three cardiac GATAs, GATA-4 is by far the most extensively studied, however, loss-of-function data question its presumed dominance during heart development as opposed to hypertrophy. (C) 2004 Elsevier Ltd. All rights reserved.
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