Antiproliferative effects of daucane esters from Ferula communis and F. arrigonii on human colon cancer cell lines

Certain jaesekanadiol p-hydroxy- and p-methoxybenzoates - typical of Ferula communis and Ferula arrigonii sardinian plants - show antiproliferative activity on human colon cancer less. The inhibitory doses 50%, calculated after 72 h of treatment, revealed that the antiproliferative capacity of the compounds was in the following descending order: ferutinin > 2 alpha-OH-ferutidin > ferutidin > siol anisate > lapiferin > jaeskeanadiol. Evidence is presented that interaction with type II estrogen -binding sites (EBS) underlies this activity. Copyright (c) 2005 John Wiley & Sons, Ltd.