Journal
DRUG DISCOVERY TODAY
Volume 10, Issue 3, Pages 177-189Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1359-6446(04)03321-5
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Relevance of a drug target for a disease is often inferred with strong belief but fragile evidence Here a., program for early identification of human disease-specific drug targets using high-throughput genetic associations is described. Large numbers of well-characterized patients (>1000) and matched controls are screened for genetic associations using several thousand (>7000) single nucleotide polymorphisms from more than 1500 genes. The genes were selected because they are members of target classes for which there are precedents for high-throughput chemical screening technology. This review summarizes the methods and intensive data analyses leading to target gene identification for type 2 diabetes mellitus, including the statistical permutation methodology used to correct for many variables.
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