Journal
INFECTION AND IMMUNITY
Volume 73, Issue 2, Pages 1196-1203Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.73.2.1196-1203.2005
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Funding
- NIAID NIH HHS [R37 AI026170, R01 AI026170, AI 26170] Funding Source: Medline
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We report the safety and immunogenicity of a double lysine and pantothenate auxotroph of Mycobacterium tuberculosis in mice. The DeltalysDelta DeltapanCD mutant is completely attenuated in immunocompromised SCID and gamma interferon knockout mice yet induces short-term and long-term protection in immunocompetent and CD4-deficient mice following single-dose subcutaneous vaccination.
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