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Cadherins and catenins in synapse development

Journal

CURRENT OPINION IN NEUROBIOLOGY
Volume 15, Issue 1, Pages 73-80

Publisher

CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2005.01.001

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Cadherin-catenin complexes have been well established as key regulators of cell adhesion. Recent work has elucidated a pivotal role for these molecules in synaptic assembly, remodelling and plasticity. Far from being mere adhesive scaffolds, cadherins might directly regulate cell signalling to modulate synaptic connectivity.

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