Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 159, Issue 1-2, Pages 97-105Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2004.10.003
Keywords
cannabidiol; marijuana; macrophage; IL-12; IL-10; chemotaxis
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Cannabidiol is the main nonpsychoactive component of marijuana. We examined the ability of in vivo and in vitro cannabidiol to interfere with the production of interleukin (IL)-12 and IL-10 by murine macrophages and to modulate macrophage chemotaxis. Cannabidiol added in vitro to peritoneal macrophages significantly increased IL-12 and decreased IL-10 production. The CB1 and CB2 receptor antagonists prevented this modulation. Macrophages from animals treated with cannabidiol at the dose of 30 mg kg(-1) either orally or i.p. produced higher levels of IL-12 and lower levels of IL-10 in comparison to controls, and the CB receptor antagonists did not prevent these effects. Cannabidiol dose-dependently decreased fMLP-induced chemotaxis of macrophages, and the CB2 receptor antagonist prevented this decrease. (C) 2004 Elsevier B.V. All rights reserved.
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