Action of pyrazoline-type insecticides at neuronal target sites

Pyrazoline-type insecticides were discovered in the early 1970s, but did not readily yield commercial insecticide products due to their unfavorable toxicity profiles and environmental properties. The recent registration of indoxacarb, a compound derived from pyrazolines, has drawn renewed attention to this insecticide class. This review summarizes the development of the pyrazoline-type insecticides and examines the mechanism of action of these compounds based on available electrophysiological, pharmacological, and toxicological information. (C) 2004 Elsevier Inc. All rights reserved.