Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 6, Issue 2, Pages 127-138Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1568
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In the RNA-interference pathway, double-stranded RNA induces sequence-specific mRNA degradation through the action of the RNA-induced silencing complex ( RISC). Recent work has provided our first glimpses of the RISC-assembly pathway and uncovered the biochemical roles of critical RISC components. These advances have taken our mechanistic understanding of RNA interference to a new level and promise to improve our ability to exploit this biological process for use in experimental biology and medicine.
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