Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 28, Issue 2, Pages 380-382Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.28.380
Keywords
Angelica dahurica; sepsis; lipopolysaccharide; furnaocoumarin; tumor necrosis factor-alpha; alanine aminotransferase
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In the course of isolating agents preventing sepsis from the EtOAc extract of the roots of Angelica dahurica, four known furanocoumarins, isoimperatorin (1), oxypeucedanin (2), (+/-)-byakangelicin (3), and (+)oxypeucedanin hydrate (4), were isolated as active compounds based on the in vivo assay model of sepsis induced by lipopolysaccharide (LPS) and D-galactosamine (D-GaIN). Among them, 3 showed the highest survival rate (100% with a dose of 30 mg/kg versus 20% for the control experiment) and decreased the plasma levels of tumor necrosis factor-alpha and alanine aminotransferase in mice adminstered LPS/D-GaIN.
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