Journal
VIRUS RESEARCH
Volume 107, Issue 2, Pages 215-228Publisher
ELSEVIER
DOI: 10.1016/j.virusres.2004.11.011
Keywords
HIV-1; retroviruses; lethal mutagenesis
Categories
Funding
- NCI NIH HHS [CA39903] Funding Source: Medline
- NIAID NIH HHS [AI34834, AI10139, AI42570] Funding Source: Medline
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HIV-1 and other retroviruses exhibit mutation rates that are 1,000,000-fold greater than their host organisms. Error-prone viral replication may place retroviruses and other RNA viruses near the threshold of error catastrophe or extinction due to an intolerable load of deleterious mutations. Strategies designed to drive viruses to error catastrophe have been applied to HIV-1 and a number of RNA viruses. Here, we review the concept of extinguishing HIV infection by lethal mutagenesis and consider the utility of this new approach in combination with conventional antiretroviral strategies. (C) 2004 Published by Elsevier B.V.
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