Journal
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
Volume 288, Issue 2, Pages G403-G406Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00357.2004
Keywords
ulcerative colitis
Categories
Funding
- NIDDK NIH HHS [R-01-DK-061417, R-01-DK-002802, R24-DK-064399] Funding Source: Medline
Ask authors/readers for more resources
Crohn's disease (CD) is driven by seemingly aberrant immune responses directed toward commensal enteric microflora. However, the specific antigens targeted by this immune response remain largely undefined. Herein, we demonstrate that common enteric flagellins are one such target of the CD-associated immune response. Thus flagellin may not only drive acute inflammation via activation of Toll-like receptor 5-mediated gene expression but may also serve as a target of the adaptive immune response that maintains the chronic inflammation characteristic of CD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available