Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 20, Issue 2, Pages 318-329Publisher
WILEY
DOI: 10.1359/JBMR.041109
Keywords
metastasis; chemokine; marrow; prostate cancer; bone
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Funding
- NCI NIH HHS [CA93900, P50 CA69568, P01 CA46952] Funding Source: Medline
- NIAMS NIH HHS [R01 AR46024] Funding Source: Medline
- NIDCR NIH HHS [R01 DE13701] Funding Source: Medline
- NIDDK NIH HHS [DK067688] Funding Source: Medline
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To delineate the role of SDF-1 and CXCR4 in metastatic prostate cancer (CaP), positive correlations were established between SDF-1 levels and tumor metastasis. Neutralization of CXCR4 limited the number and the growth of intraosseous metastasis in vivo. Together, these in vivo metastasis data provide critical support that SDF-1/CXCR4 plays a role in skeletal metastasis.
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