Embryonic and fetal development in a commercial dam-line genotype

During depopulation of a breeding unit within Swine Graphics Enterprises, extensive data were collected and used to examine relationships among ovulation rate, the pattern of prenatal loss, and placental and fetal development. Groups of Large White x Landrace females (n = 447) were slaughtered between day 20-30, 50-55 or 85-90 of gestation, with approximately equal numbers of animals representing kilts and parity 1 (G/P1), parity 2-3 (P2/3), and parity >4 (P4+). Ovulation rate and embryo number were recorded for all animals. With the exception of the G/P1 animals, embryonic and placental weight were recorded for four conceptuses per sow on day 20-30; on day 85-90 two conceptuses per sow were dissected to determine placental and fetal development. Ovulation rate (22.7 +/- 0.2 overall) was higher(P < 0.05) in P2/3 (23.6 +/- 0.4) and P4+ (24.7 +/- 0.4) than in G/P1 (20.2 +/- 0.5). Embryonic/fetal survival was 61.8 +/- 2.1% at day 20-30, 50.2 +/- 2.2%at day 50-55 and 48.7 +/- 1.9% at day 85-90 and the number of surviving conceptuses was higher:(P < 0.05),in the P2/3 sows,than in other parity groups. There was no relationship between ovulation rate and number of live embryos at day 20-30 or 85-90. At day 20-30 and 85-90, embryo weight was positively correlated with placental weight, but neither placental weight nor embryonic/fetal weight was correlated with number of viable embryos. A parity by gestation day interaction existed; placental weight for P4+ (3.42 +/- 0.43g) was less than for P2/3 (7.55 +/- 0.40 g) at day 20-30 (P < 0.0001), whereas at day 85-90, Placental weight of P2/3 (209.5 +/- 8.5 g) was less (P = 0.05) than both G/P1 (235.7 +/- 7.3 g):and P4+ (235.4 +/- 7.1 g). At day 85-90, fetal brain weight, relative to body weight (R-2 = 0.61, P < 0.0001), and fetal brain:liver weight ratio (R-2 = 0.35; P < 0.0001) were negatively related to mean fetal weight,:and brain:liver weight ratio showed a trend towards a relationship with number of viable fetuses (P = 0.08). Parity also affected brain:liver weight ratio,(P = 0.01). Clearly, high ovulation rates in the higher-parity sows have the potential to,cause excessive in utero crowding of conceptuses in the post-implantation period. Even with moderate crowding, increased brain:liver weight ratios in smaller fetuses in late gestation indicate that uterine capacity impacts fetal development as well as the number of surviving fetuses. (C) 2004 Elsevier B.V. All rights reserved.