Journal
INTERNATIONAL JOURNAL OF HEMATOLOGY
Volume 81, Issue 2, Pages 100-105Publisher
SPRINGER JAPAN KK
DOI: 10.1532/IJH97.04193
Keywords
GPIIb-IIIa; autoantibody; thrombocytopenia; Glanzmann thrombasthenia
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Chronic immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by early platelet destruction mediated by antiplatelet autoantibodies. Platelet membrane glycoproteins (GP), especially GPIIb-IIIa and GPIb-IX, contain major autoantigenic determinants in chronic ITP. Recent advances in the localization of autoantigens as well as in the detection of GP-specific antibodies have improved our understanding of the pathophysiology of the disease. The N-terminal globular head of GPIIb-IIIa, particularly the beta-propeller domain in GPIIb, seems to play an important role as a hot spot for autoantigenic epitopes in chronic ITP. (C)2005 The Japanese Society of Hematology.
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