Journal
TRENDS IN MICROBIOLOGY
Volume 13, Issue 2, Pages 52-56Publisher
CELL PRESS
DOI: 10.1016/j.tim.2004.12.006
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Two-component systems that link environmental signals to cellular responses are viewed as the primary mode of signal transduction in prokaryotes. By analyzing information encoded by 145 prokaryotic genomes, we found that the majority of signal transduction systems consist of a single protein that contains input and output domains but lacks phosphotransfer domains typical of two-component systems. One-component systems are evolutionarily older, more widely distributed among bacteria and archaea, and display a greater diversity of domains than two-component systems.
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