Journal
VIRUS RESEARCH
Volume 107, Issue 2, Pages 117-127Publisher
ELSEVIER
DOI: 10.1016/j.virusres.2004.11.002
Keywords
quasispecies; replication; selection; mutation; sequence heterogeneity
Categories
Ask authors/readers for more resources
Basic principles underlying the population dynamics of bacteria and viruses are presented, with emphasis on RNA viruses. Concepts reviewed here include fitness, mutant generation, competition, selection, sequence space and the theoretical origins of quasispecies. A wild-type virus is no longer viewed as the fittest type, but as the center of gravity of a population landscape. A consequence of quasispecies is the existence of an error threshold for selective competence. The error threshold has a justification in quasispecies theory and lends itself to exploration of strategies to drive viral populations over the error threshold, the central theme of this volume. (C) 2004 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available