Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 5, Issue 2, Pages 407-415Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2004.10.007
Keywords
Artemisia vestita; delayed-type hypersensitivity; pieryl chloride; contact sensitivity; matrix metalloprotein; adhesion
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In the present paper. the effect of the aqueous extract from aerial parts of Artemisia vestita (AV-ext), a traditional Tibetan medicine, on ear contact sensitivity was examined. AV-ext significantly reduced the ear swelling when administered during the induction phase of picryl-chloride (PCI)-induced ear contact sensitivity in mice. The extract also showed a dose-dependent inhibition on lymphocyte proliferation and IL-2 production in Con A-activated spleen cells. The proliferation inhibition was confirmed in the mixed lymphocytes reaction. Furthermore. the adhesion of the isolated spleen cells from PCI-sensitized mice to type IV collagen was significantly decreased in a dose-dependent manner by AV-ext. Such decrease was also Seen in Av-ext-treated Jurkat T cells and the T cells purified from above spleen cells. The purified spleen T cells from PCI-semitized mice produced more matrix metalloproteinase-9 (MMP-9) than naive T cells. and AV-ext remark-ably reduced MMP-9 production both in vivo and in vitro. These results suggest that AV-ext may alleviate contact sensitivity through blocking the activation of T lymphocytes and decreasing their localization to the inflammatory sites via down-regulating the potential of cell adhesion and metalloproteinase production. (C) 2004 Elsevier B.V. All rights reserved.
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