Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 99, Issue 2, Pages 546-551Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2004.10.033
Keywords
oxovanadium; alpha-furancarboxylic acid; insulinomimetic activity
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Bis(alpha-furanearboxylato)oxovanadium(IV) - a new orally active antidiabetic vanadyl complex has been synthesized, characterized, and tested for bioactivity as insulin-enhancing agents. The complex was administered intragastrically to both normal and STZ-diabetic rats for 4 weeks. The results show that the complex at a dose of 10.0 and 20.0 mg V kg(-1), could significantly lower the blood glucose level rats and ameliorated impaired glucose tolerance in STZ-diabetic, but not in normal rats. It was suggested that the complex exerted an antidiabetic effect in STZ-diabetic rats, which maybe was related to increasing the sensitivity to insulin. (C) 2004 Elsevier Inc. All rights reserved.
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