Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 72, Issue 2, Pages 89-93Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2004.11.001
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Funding
- NINDS NIH HHS [P50 NS-23327] Funding Source: Medline
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Cyclooxygenase-2 (COX-2) plays a key role in diverse inflammatory conditions. Its cellular levels depend on transcriptional activation by pro-inflammatory mediators. The mechanism by which phorbol esters and cytokines activate COX-2 gene expression has been extensively characterized. Several endogenous molecules and natural products have been reported to inhibit COX-2 expression by targeting at the transcriptional activation induced by pro-inflammatory mediators. This review highlights the importance of C/EBPbeta and NF-kappaB in COX-2 transcriptional activation by proinflammatory mediators and as targets of inhibition by endogenous molecules such as melatonin and natural products including salicylate and polyphenols. (C) 2004 Elsevier Ltd. All rights reserved.
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