Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 15, Issue 3, Pages 729-732Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.11.016
Keywords
DNA polymerase; replication; competitive inhibitors; antibacterial; broad spectrum
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Funding
- NIAID NIH HHS [AI51103] Funding Source: Medline
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7- substituted- N 2 -(3,4-dichlorobenzyl)guanines potently and competitively inhibit DNA polymerases IIIC and IIIE from Gram+ bacteria. Certain derivatives are also competitive inhibitors of DNA polymerase IIIE from Gram- bacteria. (C) 2004 Elsevier Ltd. All rights reserved.
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