Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 13, Issue 3, Pages 773-783Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2004.10.037
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Several novel antioxidant-iron chelators bearing 8-hydroxyoxyquinoline moiety were synthesized, and various properties related to their iron chelation, and neuroprotective action were investigated. All the chelators exhibited strong iron(III) chelating and high antioxidant properties. Chelator 9 (HLA20). having good permeability into K562 cells and moderate selective MAO-B inhibitory activity (IC50 110 muM), displayed the hightest protective effects against differentiated P19 cell death induced by 6-hydroxydopamine. EPR studies suggested that Chelator 9 also act as radical scavenger to directly scavenge hydroxyl radical. (C) 2004 Elsevier Ltd. All rights reserved.
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