Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 159, Issue 1-2, Pages 215-224Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2004.10.009
Keywords
amyotrophic lateral sclerosis (ALS); Alzheimer's disease (AD); motor neuron disease; immune activation; monocyte/macrophage
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Funding
- NCI NIH HHS [U01-CA66529] Funding Source: Medline
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Sporadic amyotrophic lateral sclerosis (sALS) is a progressive neuroinflammatory disease of spinal cord motor neurons of unclear etiology. Blood from 38 patients with sALS, 28 aged-match controls, and 25 Alzheimer's disease (AD) patients were evaluated and activated monocyte/macrophages were observed in all patients with sALS and AD; the degree of activation was directly related to the rate of sALS disease progression. Other parameters of T-cell activation and immune globulin levels showed similar disease associated changes. These data are consistent with a disease model previously suggested for AD, wherein systemic immunologic activation plays an active role in sALS. (C) 2004 Elsevier B.V. All rights reserved.
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