Journal
CELL MOTILITY AND THE CYTOSKELETON
Volume 60, Issue 2, Pages 121-128Publisher
WILEY-LISS
DOI: 10.1002/cm.20050
Keywords
actoclampin; tethered-ratchet; polymerization motor; molecular motor; Ena/VASP proteins; end-tracking motor
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Funding
- NIGMS NIH HHS [GM 67828] Funding Source: Medline
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Listeria monocytogenes forms right-handed helical rocket tail trajectories during actin-based motility in cell-free extracts, and this stereochemical feature is consistent with actoclampin's affinity-modulated, clamped-filament elongation model [Dickinson and Purich, 2002: Biophys J 82:605-617]. In that mechanism, right-handed torque is generated by an end-tracking molecular motor, each comprised of a filament barbed end and clamping protein that processively traces the right-handed helix of its filament partner. By contrast, torque is not a predicted property of those models (e.g.. elastic propulsion, elastic Brownian ratchet. tethered ratchet, and insertional polymerization models) requiring filament barbed ends to depart/detach from the motile object's surface during/after each monomer-addition step. Helical trajectories also explain why Listeria undergoes longitudinal-axis rotation on a length-scale matching the helical periodicity of Listeria'S rocket tails. (C) 2004 Wiley-Liss. Inc.
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