Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 191, Issue 3, Pages 367-371Publisher
UNIV CHICAGO PRESS
DOI: 10.1086/427194
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Funding
- NCI NIH HHS [CA79389] Funding Source: Medline
- NIAID NIH HHS [AI41536, AI42499, AI32257] Funding Source: Medline
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Inguinal lymph nodes from 24 human immunodeficiency virus (HIV) type 1-infected subjects without Kaposi sarcoma-associated herpesvirus (KSHV)-associated diseases were examined for KSHV infection. KSHV-infected cells were detected at a very low frequency in the lymph nodes of 7 subjects (median frequency, 2 infected cells/10(7) lymph node cells). Latent, but not lytic, KSHV gene expression was detected and KSHV-infected cells were located in B cell-rich areas of lymph node follicles. These findings provide evidence that, in the absence of KSHV-associated diseases, latent infection of lymph node cells provides a mechanism for the persistence of KSHV in KSHV/HIV-1-coinfected persons.
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