Journal
JOURNAL OF NEUROSCIENCE
Volume 25, Issue 5, Pages 1304-1310Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4745.04.2005
Keywords
TRPV4; thermosensation; warm; heat; temperature; pain
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Transient receptor potential vanilloid 4 (TRPV4), a cation channel responsive to hypotonicity, can also be activated by warm temperatures. Moreover, TRPV4(-/-) mice reportedly exhibit deficits in inflammation-induced thermal hyperalgesia. However, it is unknown whether TRPV4 or related transient receptor potential channels account for warmth perception under injury-free conditions. We therefore investigated the contribution of TRPV4 to thermosensation and thermoregulation in vivo. On a thermal gradient, TRPV4(-/-) mice selected warmer floor temperatures than wild-type littermates. In addition, whereas wild-type mice failed to discriminate between floor temperatures of 30 and 34 degreesC, TRPV4(-/-) mice exhibited a strong preference for 34 degreesC. TRPV4(-/-) mice also exhibited prolonged withdrawal latencies during acute tail heating. TRPV4(-/-) and wild-type mice exhibited similar changes in behavior on a thermal gradient after paw inflammation. Circadian body temperature fluctuations and thermoregulation in a warm environment were also indistinguishable between genotypes. These results demonstrate that TRPV4 is required for normal thermal responsiveness in vivo.
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