Journal
FEBS LETTERS
Volume 579, Issue 4, Pages 938-942Publisher
WILEY
DOI: 10.1016/j.febslet.2004.11.048
Keywords
translation; rapid kinetics; accuracy
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Aminoacyl-tRNA (aa-tRNA) is delivered to the ribosome in a ternary complex with elongation factor Tu (EF-Tu) and GTP. The stepwise movement of aa-tRNA from EF-Tu into the ribosomal A site entails a number of intermediates. The ribosome recognizes aa-tRNA through shape discrimination of the codon-anticodon duplex and regulates the rates of GTP hydrolysis by EF-Tu and aa-tRNA accommodation in the A site by an induced fit mechanism. Recent results of kinetic measurements, ribosome crystallography, single molecule FRET measurements, and cryo-electron microscopy suggest the mechanism of tRNA recognition and selection. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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