Journal
MOLECULAR PAIN
Volume 1, Issue -, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1186/1744-8069-1-5
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Funding
- NIDA NIH HHS [DA08835, R01 DA008835] Funding Source: Medline
- NINDS NIH HHS [NS 45681, R01 NS045681, R01 NS042661, NS42661] Funding Source: Medline
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Glutamate transporter (GT) plays a major role in the mechanisms of glutamate homeostasis. Can this transporter system be a therapeutic target for glutamate-mediated neurological disorders? In January's edition of Nature, Rothstein et al (2005) reports that the most commonly used class of antibiotics (beta-lactam antibiotics) such as ceftriaxone promoted the expression of GLT1 and demonstrated a functional role in both in vitro and in vivo models of glutamate neurotocixity. These findings indicate that positive promoters of GT expression may have a unique role in neuroprotection through regulating GT expression. This is also encouraging in search for new pharmacological tools for pain management.
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