Journal
FEBS LETTERS
Volume 579, Issue 5, Pages 1279-1284Publisher
WILEY
DOI: 10.1016/j.febslet.2004.12.092
Keywords
small glutamine-rich TPR-containing protein; heat shock protein 70; heat shock cognate protein 70; apoptosis; TPR
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It is known that small glutamine-rich TPR-containing protein (SGT) is the member of TPR motif family. However, the biological functions of SGT remain unclear. In this paper, we report that SGT plays a role in apoptotic signaling. Ectopic expression of SGT enhances DNA fragment and nucleus breakage after the induction of apoptosis. Increasing mRNA level of SGT is also observed in 7721 cells undergoing apoptosis, knockdown the expression of endogenous SGT contributes to the decrease of apoptosis of 7721 cells. Deletion analysis reveals that TPR domain is critical to pro-apoptotic function of SGT. Furthermore, we demonstrated that the PARP cleavage and cytochrome c release are enhanced when SGT is overexpressed in 7721 cells during apoptosis. Collectively, our results indicate that SGT is a new pro-apoptotic factor. (C) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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