Journal
FEBS LETTERS
Volume 579, Issue 5, Pages 1039-1046Publisher
WILEY
DOI: 10.1016/j.febslet.2005.01.006
Keywords
GEF; Rho; DOCK9; DOCK10; DOCK11; CZH2
Funding
- PHS HHS [R01 47214] Funding Source: Medline
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A novel superfamily of guanine nucleotide exchange factors for Rho GTPases includes DOCK180 and zizimin1. The zizimin subfamily includes three genes of which only zizimin1 has been cloned. We report here the cloning of zizimin2, identified in a screen for genes enriched in germinal center B cells. Zizimin2 and zizimin1 have similar primary structures and both proteins bound and activated Cdc42 but not the Cdc42-related proteins TC10 or TCL. Their tissue distributions are distinct, however, with zizimin2 expressed predominantly in lymphocytes and an opposite pattern for zizimin1. Zizimin3 was also analyzed and showed distinct GTPase specificity and tissue distribution. (C) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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