Journal
TETRAHEDRON LETTERS
Volume 46, Issue 7, Pages 1173-1175Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.12.066
Keywords
total synthesis; alkaloids; pyrroles; hydrogenation
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Addition of a propargyl Grignard reagent to 3,4-dihydro-6,7-dimethoxyisoquinoline, silver(I)-promoted oxidative cyclization, and chemoselective hydrogenation of the pyrrole ring provide a simple three-step route to the antitumor active pyrrolo[2,1-a]isoquinoline alkaloid (+/-)-crispine A. (C) 2004 Elsevier Ltd. All rights reserved.
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