Journal
GENE
Volume 346, Issue -, Pages 153-161Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2004.10.014
Keywords
pathogen protozoan; chromosome end organization; surface protein genes; retrotransposon Hot Spot multigene family; telomere healing
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Funding
- NIAID NIH HHS [U01 AI045038] Funding Source: Medline
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Here, we sequenced two large telomeric regions obtained from the pathogen protozoan Trypanosoma cruzi. These sequences, together with in silico assembled contigs, allowed us to establish the general features of telomeres and subtelomeres of this parasite. Our findings can be summarized as follows: We confirmed the presence of two types of telomeric ends; subtelomeric regions appeared to be enriched in (pseudo)genes of RHS (retrotransposon hot spot), TS (trans-sialidase)-like proteins, and putative surface protein DGF-1 (dispersed gene family-1). Sequence analysis of the ts-like genes located at the telomeres suggested that T. cruzi chromosomal ends could have been the site for generation of new gp85 variants, an important adhesin molecule involved in the invasion of mammalian cells by T. cruzi. Finally, a mechanism for generation of T. cruzi telomere by chromosome breakage and telomere healing is proposed. (c) 2004 Elsevier B.V. All rights reserved.
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