Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 690, Issue 4, Pages 932-938Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2004.10.037
Keywords
palladium; nickel; biaryls cross-coupling; homogeneous catalysis
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Biaryl compounds are prevalent in both nature and in active pharmaceutical ingredients. The palladium and nickel catalyzed cross-coupling of aryl Grignard reagents with aryl fluorides reported herein affords moderate to excellent yields of the corresponding unsymmetrical biaryls. In addition, the first example of a biaryl cross-coupling utilizing unactivated aryl fluorides under phosphine free palladium conditions is reported. Microwave technology allowed rapid optimization of catalyst systems, which identified several ligands for this cross-coupling reaction. (C) 2004 Elsevier BN. All rights reserved.
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