Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 191, Issue 4, Pages 619-626Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/427243
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Funding
- MRC [G84/6323] Funding Source: UKRI
- Medical Research Council [G84/6323] Funding Source: researchfish
- Medical Research Council [G84/6323] Funding Source: Medline
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We calculated the number and growth rate of Plasmodium falciparum parasites emerging in recipients of candidate preerythrocytic malaria vaccines and unvaccinated control subjects undergoing mosquito-bite challenge. This was done to measure vaccine efficacy and to distinguish the effects on blood-stage multiplication from those on liver-stage parasites. Real-time polymerase chain reaction measurements of parasite densities were analyzed by nonlinear regression and mixed-effects models. Substantial reductions in numbers of liver parasites resulted from the use of 2 immunization regimens: FP9 boosted by modified virus Ankara (MVA) encoding the malaria epitope-thrombospondin-related adhesion protein insert (92% reduction) and RTS, S/AS02 used in heterologous prime-boost immunization regimens, with MVA encoding the circumsporozoite protein (97% reduction). Forty-eight-hour growth rates in blood from control subjects were not different from those in blood from any vaccination group (mean, 14.4-fold [95% confidence interval, 11-19- fold]).
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