Journal
ANALYTICAL CHEMISTRY
Volume 77, Issue 4, Pages 1177-1182Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac048444r
Keywords
-
Categories
Ask authors/readers for more resources
We describe the use of liquid-phase continuous-wave cavity ring-down spectroscopy for the detection of an HPLC separation. Ibis technique builds on earlier work by Snyder and Zare using pulsed laser sources and improves upon commercially available UV-visible detectors by a factor of up to 50. The system employs a compact doubled-diode single-mode continuous-wave laser operating at 488 nm and a previously described Brewster's angle flow cell. Ring-down time constants as long as 5.8 mus were observed with liquid samples in a 0.3-mm path length cell. The baseline noise during an HPLC separation was only 2 x 10(-7) absorbance units (AU) peak to peak, as compared to 1 x 10(-5) AU for a state-of-the-art commercial UV-visible detector.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available