Journal
CANCER
Volume 103, Issue 4, Pages 756-762Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/cncr.20841
Keywords
hepatocellular carcinoma; chemotherapy; metastasis; 5-fluorouracil; mitoxantrone; cisplatin
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BACKGROUND. The aim of the current study was to evaluate the antitumor activity and toxicity of continuous infusion of 5-fluorouracil, mitoxantrone, and cisplatin (FMP therapy) in chemotherapy-naive patients with metastatic hepatocellular carcinoma (HCC). METHODS. Fifty-one patients with metastatic HCC who had not undergone previous systemic chemotherapy were enrolled. The therapy consisted of intravenous administration of 80 mg/m(2) cisplatin and 6 mg/m(2) mitoxantrone on Day 1 and continuous intravenous infusion of 450 mg/m(2) 5-fluorouracil per day on Days 1-5. The treatment was repeated every 4 weeks for a maximum of 6 courses with dose adjustments based on the observed toxic effects if there was no evidence of tumor progression or unacceptable toxicity. RESULTS. Of the 51 enrolled patients, 14 (27%) achieved a partial response (95% confidence interval, 16-42%) with a median duration of 7.6 months (range, 2.3-18.4 months). Twenty-seven patients (53%) showed no change and 9 (18%) had progressive disease. The median survival time, 1-year survival rate, and median progression-free survival time for all patients were 11.6 months, 44.3%, and 4.0 months, respectively. The main Grade 3 and 4 toxicities were leukocytopenia (67%), neutropenia (71%), thrombocytopenia (27%), and elevated levels of aspartate aminotransferase (37%) and alanine aminotransferase (41%). These symptoms were generally brief and reversible, with the exception of one treatment-related death due to acute hepatic failure. CONCLUSIONS. FMP therapy had significant antitumor activity with acceptable toxicity in patients with metastatic HCC. (C) 2005 American Cancer Society.
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