Journal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 145, Issue 2-3, Pages 209-218Publisher
ELSEVIER
DOI: 10.1016/j.resp.2004.06.010
Keywords
disease, pulmonary edema; exercise, pulmonary edema; gas exchange, lung diffusing capacity; mammals, humans
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To determine whether intense, prolonged activity can induce transient pulmonary edema, eight highly trained male cyclists (mean +/- S.D.: age, 26.9 +/- 3.0 years; height, 179.9 +/- 5.7 cm; weight, 76.1 +/- 6.5 kg) performed a 45-min endurance cycle test (ECT). V-O2,V-max was determined (4.84 +/- 0.4 L min(-1), 63.7 +/- 2.6 ml min(-1) g(-1)) and the intensity of exercise for the ECT was set at 10% below ventilatory threshold (similar to76% V-O2,V-max 300 +/- 25 W). Pre- and post-exercise pulmonary diffusion (DLCO) measurements and magnetic resonance imaging of the lung were made. DLCO and pulmonary capillary blood volume (VC) decreased I h post-exercise by 12% (P = 0.004) and 21% (P = 0.017), respectively, but no significant change in membrane diffusing capacity (DM) was found. The magnetic resonance scans demonstrated a 9.4% increase (P = 0.043) in pulmonary extravascular water 90 min post-exercise. These data support the theory that high intensity, sustained exercise in well-trained athletes can result in transient pulmonary edema. (C) 2004 Elsevier B.V. All rights reserved.
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