Journal
SYNTHESIS-STUTTGART
Volume -, Issue 3, Pages 442-446Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2004-837299
Keywords
synthesis; 6-APA; silver triazole; beta-lactamase inhibitor; isomeric
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Tazobactam (9) was synthesized in 8 steps from the readily accessible 6-APA. By the first use of silver triazole as reactant, the formation of the isomer 7 was avoided and a total yield of 50%, which was two to three times higher than that of reported procedures for 9, was obtained.
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