4.8 Article

Radical trifluoromethylation of titanium ate enolate

Journal

ORGANIC LETTERS
Volume 7, Issue 4, Pages 649-651

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol047565a

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The radical trifluoromethylation of ketone titanium ate enolates gave alpha-CF3 ketones in good yields. The use of excess amount of LDA and Ti((OPr)-Pr-i)(4) in the preparation of titanium ate enolates is the key to the efficient radical trifluoromethylation.

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