Oxaziridine-mediated amination of primary amines: Scope and application to a one-pot pyrazole synthesis

[GRAPHICS] Electrophilic amination of primary aliphatic and aromatic amines is reported using a diethylketomalonate-derived oxaziridine to afford the corresponding N-Boc hydrazines in good to excellent yields. The method allows a one-pot synthesis of pyrazoles from primary amines.