Journal
TETRAHEDRON LETTERS
Volume 46, Issue 8, Pages 1341-1344Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.12.110
Keywords
Xylaria mellisii; anti-HSV-1; mellisol; 1,8-dihydroxynaphthol 1-O-alpha-glucopyranoside
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A structurally unique polyketide, mellisol (1) and 1,8-dihydroxynaphthol 1-O-alpha-glucopyranoside (3), were isolated from the fungus Xylaria mellisii (BCC 1005). The relative stereostructure of 1 was determined on the basis of X-ray crystallographic data. Compounds 1 and 3 exhibited activity against herpes simplex virus-type 1 with IC50 values of 10.50 and 8.40 mug/mL, respectively. They also showed cytotoxic activity against vero cells at the concentration of 40-50 mug/mL. (C) 2004 Elsevier Ltd. All rights reserved.
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