Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 201, Issue 4, Pages 489-492Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20050179
Keywords
-
Categories
Ask authors/readers for more resources
The mechanism by which the ligand occupancy state of the T cell receptor complex is converted into intracellular signaling information has been a controversial topic. Although the majority of structural studies argue against a conformational change, recent studies support the possibility for such a change within the CD3 components of the TCR complex. In this commentary, the evidence for TCR conformational change is reviewed and potential mechanisms for its initiation are explored.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available