Journal
TETRAHEDRON LETTERS
Volume 46, Issue 8, Pages 1377-1381Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.12.133
Keywords
amides; phosphines; Suzuki reaction; aryl chlorides
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A family of air-stable amide-derived phosphine (Aphos) ligands engineered on simple N,N-dialkyl aryl amide scaffolds has been designed and prepared by one-pot synthesis from the amides in high yields. The Aphos ligands have been used, in analogous to their atropisomeric variations, as hemilabile bidentate P,O-ligands in various Pd-catalyzed C-N and C-C bond forming reactions. We present here our results on the highly efficient Suzuki cross-coupling reactions of unactivated and/or sterically hindered aryl chlorides with arylboronic acids and a relationship of Aphos structures with catalytic efficacy. (C) 2005 Elsevier Ltd. All rights reserved.
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