Journal
NEUROLOGY
Volume 64, Issue 4, Pages 746-750Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.WNL.0000151970.29205.70
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Funding
- NINDS NIH HHS [P05 NS02808, R01 NS39505, R01 NS38992] Funding Source: Medline
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Children undergoing surgery with infant-onset epilepsy were classified into those with medically refractory infantile spasms ( IS), successfully treated IS, and no IS history, and the groups were compared for pre- and postsurgery clinical and Vineland Adaptive Behavior Scale (VABS) developmental quotients (DQ). Children without an IS history were older at surgery and had longer epilepsy durations than those with IS despite similar substrates, surgeries, and seizure frequencies. In all groups, better postsurgery VABS-DQ scores were associated with early surgical intervention indicating that infant-onset epilepsy patients with or without IS are at risk for seizure-induced encephalopathy.
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