Journal
MACROMOLECULAR BIOSCIENCE
Volume 5, Issue 2, Pages 107-111Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200400140
Keywords
biocompatibility; chitosan; hydrogels; poly(ethylene glycol); viscosity
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PEG-grafted chitosan was formulated such that its solution undergoes a thermally reversed phase transition from an injectable free-flowing solution at low temperature to a gel at body temperature. Aqueous solutions of PEG-grafted chitosan can be prepared at physiological pH values, thereby allowing safe incorporation of bioactive molecules. This injectable thermoreversible hydrogel is potentially suitable for a wide range of biomedical applications, particularly in sustained in vivo drug release and tissue engineering.
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