Journal
CELL
Volume 120, Issue 4, Pages 545-555Publisher
CELL PRESS
DOI: 10.1016/j.cell.2005.02.008
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From Alois Alzheimer's description of Auguste D.'s brain in 1907 to George Glenner's biochemical dissection of beta-amyloid in 1984, the amyloid hypothesis of Alzheimer's disease has continued to gain support over the past two decades, particularly from genetic studies. Here we assess the amyloid hypothesis based on both known and putative Alzheimer's disease genes.
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