Journal
TETRAHEDRON LETTERS
Volume 46, Issue 9, Pages 1447-1450Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2005.01.018
Keywords
Pd complex; fluorination; beta-ketophosphonate; asymmetric catalysis
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On the basis of our Pd enolate chemistry, we have succeeded in developing an efficient catalytic enantioselective fluorination of beta-ketophosphonates. In the presence of chiral Pd complexes 1 (1-10 mol %), various substrates including cyclic and acyclic beta-ketophosphonates underwent the reaction with N-fluorobenzenesulfonimide (NFS1) in EtOH to give the corresponding fluorinated products in a highly enantioselective manner (94-98% ee). (C) 2005 Elsevier Ltd. All rights reserved.
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