Journal
PSYCHIATRY RESEARCH
Volume 133, Issue 2-3, Pages 273-276Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2004.02.018
Keywords
atypical antipsychotics; atypical neuroleptics; clinical response; body mass index
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Clozapine is an atypical antipsychotic known to cause considerable weight gain. The extent to which genetic factors determine weight gain is unknown. Here we report on a pair of female monozygotic twins concordant for schizophrenia and mild mental retardation who were treated with clozapine over 5.5 years. One twin gained a total of 53.1 kg and had a weight of 107.5 kg (BMI=38.1 kg/m(2)) at the end of the observation period. The other twin gained a total of 48.2 kg and finally had a weight of 100.4 kg (BMI-33.8 kg/m(2)). Because both patients experienced considerable weight gain during treatment, our observation suggests that the antipsychotic-induced weight gain is under strong genetic control. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
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