Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 49, Issue 3, Pages 1181-1183Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.49.3.1181-1183.2005
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Funding
- NIAID NIH HHS [P01-AI-37940, P01 AI037940] Funding Source: Medline
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Zinc salt solutions administered as topical microbicides provided significant protection against herpes simplex virus type 2 infection in a mouse vaginal challenge model. However, at the therapeutic concentration, the salt solutions caused sloughing of sheets of vaginal epithelial cells. These observations limit the utility of zinc salts as microbicides and suggest that the application of zinc solutions to mucosal surfaces has the potential to cause damage that might increase susceptibility to secondary infections at a later time.
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