Journal
NATURE REVIEWS CANCER
Volume 5, Issue 3, Pages 231-237Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc1560
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The inactivation of programmed cell death, or apoptosis, is central to the development of cancer. This disabling of apoptotic responses might be a major contributor both to treatment resistance and to the observation that, in many tumours, apoptosis is not the main mechanism for the death of cancer cells in response to common treatment regimens. Importantly, this suggests that other modes of cell death are involved in the response to therapy.
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