Journal
MEMORIAS DO INSTITUTO OSWALDO CRUZ
Volume 100, Issue -, Pages 199-203Publisher
FUNDACO OSWALDO CRUZ
DOI: 10.1590/S0074-02762005000900034
Keywords
adherence; apoptosis; cytokine; O157 : H7; Shiga-like toxin; verotoxin
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Enterohemorrhagic Escherichia coli, including the serotype O157:117 that is most commonly identified with human disease, cause both sporadic cases and outbreaks of non-bloody diarrhea and hemorrhagic colitis. In about 10 % of infected subjects, the hemolytic uremic syndrome (hemolytic anemic, thrombocytopenia, and acute renal failure) develops, likely as a consequence of systemic spread of bacterial-derived toxins variously referred to as Shiga-like toxin, Shiga toxin, and Verotoxin. Increasing evidence points to a complex interplay between bacterial products -for example, adhesins and toxins - and host signal transduction pathways in mediating responses to infection. Identification of critical signaling pathways could result in the development of novel strategies for intervention to both prevent and treat this microbial infection in humans.
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